Journal of Epilepsy Research

Anti-convulsant Effects of Scutellarein in a PTZ Kindling Model in Mice

Investigation of the Antiepileptic Effect of (R)-(-) and (S)-(+) Carvone in Penicillin-Induced Epileptiform Activity Model

Özge BEYAZÇİÇEK, Sumeyye ALTUN, Ersin BEYAZÇİÇEK, Şerif DEMİR

Ceftriaxone and selenium mitigate seizures and neuronal injury in pentylenetetrazole-kindled rats: Oxidative stress and inflammatory pathway

Asmaa M. Mohamed, Dina A Ali, Eman Kolieb, Eman Z. Abdelaziz

International Immunopharmacology.2023; 120: 110304. CrossRef

Ceftriaxone ameliorates hippocampal synapse loss by inhibiting microglial/macrophages activation in glial glutamate transporter-1 dependent manner in the APP/PS1 mouse model of Alzheimer’s disease

Li-Zhe Liu, Shu-Juan Fan, Jun-Xia Gao, Wen-Bin Li, Xiao-Hui Xian

Brain Research Bulletin.2023; 200: 110683. CrossRef

Delayed treatment with ceftriaxone reverses the enhanced sensitivity of TBI mice to chemically-induced seizures

Simone A. A. Romariz, Bevan S. Main, Alex C. Harvey, Beatriz M. Longo, Mark P. Burns, Dragan Hrncic

Sink or swim: Does a worm paralysis phenotype hold clues to neurodegenerative disease?

Journal of Cellular Physiology.2023;[Epub] CrossRef

An Update on the Pathways and Aspects of Epilepsy Treatment Targets

Ruksar Sande, Pravin Kale, Angel Godad, Gaurav Doshi

Current Signal Transduction Therapy.2023;[Epub] CrossRef

Can rodent models elucidate the pathomechanisms of genetic epilepsy?

British Journal of Pharmacology.2022; 179(8): 1620. CrossRef

Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation

Osama A. Abulseoud, Fawaz Alasmari, Abdelaziz M. Hussein, Youssef Sari

Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice

Longze Sha, Guanjun Li, Xiuneng Zhang, Yarong Lin, Yunjie Qiu, Yu Deng, Wanwan Zhu, Qi Xu

Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds

Abdullah A. Alamoudi, Awaad S. Alharbi, Ashraf B. Abdel-Naim, Shaimaa M. Badr-Eldin, Zuhier A. Awan, Solomon Z. Okbazghi, Osama A. A. Ahmed, Nabil A. Alhakamy, Usama A. Fahmy, Ahmed Esmat

Pharmacological upregulation of GLT-1 alleviates the cognitive impairments in the animal model of temporal lobe epilepsy

Daniel Ramandi, Mahmoud Elahdadi Salmani, Ali Moghimi, Taghi Lashkarbolouki, Masoud Fereidoni, Giuseppe Biagini

Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43

International Journal of Molecular Sciences.2021; 22(11): 5623. CrossRef

Ceftriaxone Treatment Weakens Long-Term Synaptic Potentiation in the Hippocampus of Young Rats

Tatyana Y. Postnikova, Sergey L. Malkin, Maria V. Zakharova, Ilya V. Smolensky, Olga E. Zubareva, Aleksey V. Zaitsev

International Journal of Molecular Sciences.2021; 22(16): 8417. CrossRef

Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy

Hsin‐Hua Li, Pin‐Jiun Lin, Wei‐Han Wang, Li‐Ho Tseng, Hsin Tung, Wen‐Yuan Liu, Chih‐Li Lin, Chiung‐Hui Liu, Wen‐Chieh Liao, Ching‐Sui Hung, Ying‐Jui Ho

Experimental Physiology.2021; 106(8): 1814. CrossRef

Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy

Allison R. Peterson, Terese A. Garcia, Kyle Cullion, Seema K. Tiwari-Woodruff, Ernest V. Pedapati, Devin K. Binder

Neurobiology of Disease.2021; 157: 105443. CrossRef

Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model

Chiung‐Hui Liu, Wen‐Chieh Liao, Hsin‐Hua Li, Li‐Ho Tseng, Wei‐Han Wang, Hsin Tung, Pin‐Jiun Lin, Hsin‐Tung Jao, Wen‐Yuan Liu, Ching‐Sui Hung, Chih‐Li Lin, Ying‐Jui Ho

Fundamental & Clinical Pharmacology.2021; 35(6): 1032. CrossRef

Differential effects of inhibitors of PTZ‐induced kindling on glutamate transporters and enzyme expression

Numan Taspinar, Ahmet Hacimuftuoglu, Selcuk Butuner, Basak Togar, Gokhan Arslan, Ali Taghizadehghalehjoughi, Ufuk Okkay, Erdal Agar, Robert Stephens, Hasan Turkez, A. M. Abd El‐Aty

Clinical and Experimental Pharmacology and Physiol.2021; 48(12): 1662. CrossRef

Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone

Shaimaa N. Amin, Sherif S. Hassan, Ahmed S. Khashaba, Magdy F. Youakim, Noha S. Abdel Latif, Laila A. Rashed, Hanan D. Yassa

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease

Irena Smaga, Daniel Fierro, Javier Mesa, Malgorzata Filip, Lori A Knackstedt

Neuroscience & Biobehavioral Reviews.2020; 115: 116. CrossRef

Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric Comorbidities

Michael Maes, Thitiporn Supasitthumrong, Chusak Limotai, Ana Paula Michelin, Andressa Keiko Matsumoto, Laura de Oliveira Semão, João Victor de Lima Pedrão, Estefânia Gastaldello Moreira, Andre F. Carvalho, Sunee Sirivichayakul, Décio Sabbatini Barbosa, Bu

Molecular Neurobiology.2020; 57(8): 3334. CrossRef

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels

Ceftriaxone pretreatment confers neuroprotection in rats with acute glaucoma and reduces the score of seizures induced by pentylenotetrazole in mice

Helene A. Fachim, Renato Guizzo, Alexandra O. S. Cunha, Adriana C. Pereira, Lilian C. dos Anjos, Márcia R. Mortari, Wagner F. dos Santos

Journal of Biochemical and Molecular Toxicology.2020;[Epub] CrossRef

Lizbeth Hernandez-Ronquillo, Hajar Miranzadeh Mahabadi, Farzad Moien-Afshari, Adam Wu, Roland Auer, Viktor Zherebitskiy, Ron Borowsky, Marla Mickleborough, Richard Huntsman, Mirna Vrbancic, Francisco S. Cayabyab, Changiz Taghibiglou, Alexandra Carter, Jos

Glutamate Transporters (EAAT-1–3) as a Factor in the Pathogenesis and a Potential Therapeutic Target in Epilepsy

Neuroscience and Behavioral Physiology.2020; 50(6): 777. CrossRef

Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy

Neurobiology, Functions, and Relevance of Excitatory Amino Acid Transporters (EAATs) to Treatment of Refractory Epilepsy

Aleksey V. Zaitsev, Ilya V. Smolensky, Pascal Jorratt, Saak V. Ovsepian

GLT-1 Knockdown Inhibits Ceftriaxone-Mediated Improvements on Cognitive Deficits, and GLT-1 and xCT Expression and Activity in APP/PS1 AD Mice

JunXia Gao, LiZhe Liu, Chao Liu, ShuJuan Fan, LiRong Liu, ShuFeng Liu, Xiao-Hui Xian, Wen-Bin Li

Frontiers in Aging Neuroscience.2020;[Epub] CrossRef

Astroglial Connexin43 as a Potential Target for a Mood Stabiliser

Motohiro Okada, Tomoka Oka, Misaki Nakamoto, Kouji Fukuyama, Takashi Shiroyama

International Journal of Molecular Sciences.2020; 22(1): 339. CrossRef

The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy

Faheem Hyder Pottoo, Nahida Tabassum, Md. Noushad Javed, Shah Nigar, Rouqia Rasheed, Ayash Khan, Md. Abul Barkat, Md. Sabir Alam, Amir Maqbool, Mohammad Azam Ansari, George E. Barreto, Ghulam Md Ashraf

Molecular Neurobiology.2019; 56(2): 1233. CrossRef

Targeting gap junction in epilepsy: Perspectives and challenges

Qin Li, Qiu-Qi Li, Ji-Ning Jia, Zhao-Qian Liu, Hong-Hao Zhou, Xiao-Yuan Mao

Biomedicine & Pharmacotherapy.2019; 109: 57. CrossRef

A new avenue for treating neuronal diseases: Ceftriaxone, an old antibiotic demonstrating behavioral neuronal effects

Chun-Hwei Tai, Michele Bellesi, An-Chih Chen, Chih-Li Lin, Hsin-Hua Li, Pin-Jiun Lin, Wen-Chieh Liao, Ching-Sui Hung, Rainer K. Schwarting, Ying-Jui Ho

Behavioural Brain Research.2019; 364: 149. CrossRef

Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review

Ebrahim M. Yimer, Hailemichael Zeru Hishe, Kald Beshir Tuem

Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity

Jaycie L. Loewen, Giulia Albertini, E. Jill Dahle, Hideyo Sato, Ilse J. Smolders, Ann Massie, Karen S. Wilcox

Ceftriaxone Treatment Affects EAAT2 Expression and Glutamatergic Neurotransmission and Exerts a Weak Anticonvulsant Effect in Young Rats

Zaitsev, Malkin, Postnikova, Smolensky, Zubareva, Romanova, Zakharova, Karyakin, Zavyalov

International Journal of Molecular Sciences.2019; 20(23): 5852. CrossRef

Region‐specific deletions of the glutamate transporter GLT1 differentially affect nerve injury‐induced neuropathic pain in mice

Zhuoyang Zhao, Yuichi Hiraoka, Hiroshi Ogawa, Kohichi Tanaka

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis

Mariah L Hoye, Melissa R Regan, Leah A Jensen, Allison M Lake, Linga V Reddy, Svetlana Vidensky, Jean-Philippe Richard, Nicholas J Maragakis, Jeffrey D Rothstein, Joseph D Dougherty, Timothy M Miller

Nephroprotective efficacy of ceftriaxone against cisplatin-induced subchronic renal fibrosis in rats

Mohamed M. Abdel-Daim, Yasser S. El-Sayed, Mabrouk Abd Eldaim, Abdelazim Ibrahim

Naunyn-Schmiedeberg's Archives of Pharmacology.2017; 390(3): 301. CrossRef