Journal of Epilepsy Research

The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective

Bshra A. Alsfouk, Hayder M. Al-Kuraishy, Ali K. Albuhadily, Ali I. Al-Gareeb, Ahmed M. Abdelaziz, Athanasios Alexiou, Marios Papadakis, Mubarak Alruwaili, Gaber El-Saber Batiha

Brain Research Bulletin.2025; 221: 111189. CrossRef

A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent

Shafiul Haque, Darin Mansor Mathkor, Sajad Ahmad Bhat, Abdugani Musayev, Lidiya Khituova, Seema Ramniwas, Enosh Phillips, Nitin Swamy, Suneel Kumar, Mukerrem Betul Yerer, Hardeep Singh Tuli, Vikas Yadav

Journal of Biochemical and Molecular Toxicology.2025;[Epub] CrossRef

Berberine ameliorates seizure activity and cardiac dysfunction in pentylenetetrazol-kindling seizures in rats: Modulation of sigma1 receptor, Akt/eNOS signaling, and ferroptosis

Shrouk M. Basiouny, Hala F. Zaki, Shimaa M. Elshazly, Ahmed F. Mohamed

A systematic review of the botany, ethnopharmacology, quality control, phytochemistry, pharmacology and pharmacokinetics of Corydalis yanhusuo

Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons

Can Luo, Zhi Wang, Junbao Liao, Chuanyi Fu, Fan Zhang, Jiannong Zhao

Integrated non-targeted metabolomics and network pharmacology to reveal the mechanisms of berberine in the long-term treatment of PTZ-induced epilepsy

Hailin Zhu, Ziyu Wu, Yizhou Yu, Kaile Chang, Chunfang Zhao, Ziyu Huang, Wen He, Zhong Luo, Hui Huang, Chunbo Zhang

Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review

Nahid Jivad, Saeid Heidari-Soureshjani, Hesamaldin Bagheri, Catherine M.T. Sherwin, Sahar Rostamian

Current Pharmaceutical Biotechnology.2024; 25(17): 2253. CrossRef

Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenetetrazole in zebrafish

Kanandra Taisa Bertoncello, Gabriel Rodrigues, Carla Denise Bonan

Behavioural Brain Research.2024; 466: 114981. CrossRef

Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress

Hanbing Xu, Yubo Wang, Congcong Yu, Chunhong Han, Huifei Cui

ACS Chemical Neuroscience.2024; 15(9): 1937. CrossRef

Bombax costatum Pellegr. & Vuillet attenuates pentylenetetrazol-induced seizure and cognitive impairment in rats via inhibition of oxidative stress

Hasiya Sule Buba, Sani Hyedima Garba, Joseph Vandi Zirahei, Samaila Musa Chiroma, Nathan Isaac Dibal

Role of berberine nanoformulation in epilepsy: A novel therapeutic strategy

Lekha Saha, Puja kumari, V.R. Sinha, Vipasha Gautam, Lavjot Kaur, Sunil Sharma, Amitava Chakrabarti

Berberine Alleviates Uterine Inflammation in Rats via Modulating the TLR-2/p-PI3K/p-AKT Axis

International Immunopharmacology.2024; 141: 112931. CrossRef

Pharmacological effects of Berberine – A Chinese medicine, against xenobiotics toxicity

Pharmacological Research - Modern Chinese Medicine.2024; 13: 100507. CrossRef

Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1/Nrf2 signaling axis in aged rats

Yiliang Wang, Nu Li, Xiaoyu Chen, Yue Zhao, Letian Qu, Dasheng Cai

Stem bark chloroform extract of Bombax costatum Pellegr. & Vuillet exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in rats

A. Muhammad Bello, H. Adegoke Salami, I. Samaila Malgwi, S. Musa Chiroma

Annales Pharmaceutiques Françaises.2023; 81(2): 233. CrossRef

Current understanding and future prospects on Berberine for anticancer therapy

Chemical Biology & Drug Design.2023; 102(1): 177. CrossRef

Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii-infected rat model of ketamine-induced schizophrenia

Neghin Gholizadeh, Abdolhossein Dalimi, Fatemeh Ghaffarifar, Mehryar Nader-Mohammadi, Parviz Molavi, Masoomeh Dadkhah, Soheila Molaei

BMC Complementary Medicine and Therapies.2023;[Epub] CrossRef

Prospects of new targeted nanotherapy combining liponiosomes with berberine to combat colorectal cancer development: An in vivo experimental model

Doaa Ibrahim, Safaa I. Khater, Ahmed Abdelfattah-Hassan, Leena S. Alqahtani, Aya Sh. Metwally, Shefaa M. Bazeed, Aya Elgamal, Nagwa I. Sheraiba, Elham M. Hussein, Fatmah Ali Alasmary, Gamal A. Salem, Mohamed Ali, Hala Mahfouz

International Journal of Pharmaceutics.2023; 647: 123511. CrossRef

The modulation of SIRT1 and SIRT3 by natural compounds as a therapeutic target in doxorubicin‐induced cardiotoxicity: A review

Fatemeh B. Tabrizi, Fatemeh Yarmohammadi, A. Wallace Hayes, Gholamreza Karimi

Journal of Biochemical and Molecular Toxicology.2022;[Epub] CrossRef

The Effect of Coenzyme Q10 on Liver Injury Induced by Valproic Acid and Its Antiepileptic Activity in Rats

Fahad Alqarni, Hala S. Eweis, Ahmed Ali, Aziza Alrafiah, Mohammed Alsieni, Shahid Karim, Mosleh Ayed Alkathyri

Selenium Nanoparticles with Prodigiosin Rescue Hippocampal Damage Associated with Epileptic Seizures Induced by Pentylenetetrazole in Rats

Naif E. Al Omairi, Ashraf Albrakati, Khalaf F. Alsharif, Abdulraheem S. Almalki, Walaa Alsanie, Zakaria Y. Abd Elmageed, Dalia Zaafar, Maha S. Lokman, Amira A. Bauomy, Saied K. Belal, Mohamed M. Abdel-Daim, Ahmed E. Abdel Moneim, Hussain Alyami, Rami B. K

Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms

Protective effect of N-acetyl cysteine on the mitochondrial dynamic imbalance in temporal lobe epilepsy: Possible role of mTOR

Ekram Mohammadi, Farnaz Nikbakht, Mahmoud Barati, Mehrdad Roghani, Somayeh Vazifekhah, Ali Mohammad Khanizadeh, Zahra Heidari

Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures

Priya Mishra, Jitendra Kumar Sinha, Satyendra Kumar Rajput

Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats

Fatma H. Shaker, Marwa O. El-Derany, Sara A. Wahdan, Ebtehal El-Demerdash, Hala O. El-Mesallamy

Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy

Aziza Rashed Al-Rafiah, Khlood Mohammed Mehdar, Muh-Shi Lin

Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways

Raheleh Jahanbani, Erfan Bahramnejad, Nastaran Rahimi, Hamed Shafaroodi, Nader Sheibani, Ali Akbar Moosavi-Movahedi, Ahmad Reza Dehpour, Kourosh Vahdati

Neuroprotective Effect of Bone Marrow-Derived Mesenchymal Stem Cell Secretome in 6-OHDA-Induced Parkinson’s Disease

Dhruv Mahendru, Ashish Jain, Seema Bansal, Deepti Malik, Neha Dhir, Amit Raj Sharma, Phulen Sarma, Ajay Prakash, Uma Nahar, Alka Bhatia, Shalmoli Bhattacharyya, Bikash Medhi

Regenerative Medicine.2021; 16(10): 915. CrossRef

Berberine affords protection against oxidative stress and apoptotic damage in F1 generation of wistar rats following lactational exposure to chlorpyrifos

Era Seth, Aitizaz Ul Ahsan, Surbhi Kaushal, Sweety Mehra, Mani Chopra

Pesticide Biochemistry and Physiology.2021; 179: 104977. CrossRef

Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication

Journal of Food Biochemistry.2020;[Epub] CrossRef

Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis by suppressing NF-κB and IL-6 mediated STAT3 activation

Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity

Vipin K. Verma, Salma Malik, Ekta Mutneja, Anil K. Sahu, Kumari Rupashi, Amit K. Dinda, Dharamvir S. Arya, Jagriti Bhatia

Current Molecular Pharmacology.2020; 13(4): 342. CrossRef